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Teriflunomide (Leflunomide) Promotes Cytostatic, Antioxidant, and Apoptotic Effects in Transformed Prostate Epithelial Cells: Evidence Supporting a Role for Teriflunomide in Prostate Cancer Chemoprevention

Teriflunomide (TFN) is an inhibitor of de novo pyrimidine synthesis and the active metabolite of leflunomide. Leflunomide is prescribed to patients worldwide as an immunomodulatory and anti-inflammatory disease-modifying prodrug. Leflunomide inhibited the growth of human prostate cancer xenographs i...

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Autori principali: Hail, Numsen, Chen, Ping, Bushman, Lane R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Neoplasia Press Inc. 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2887087/
https://ncbi.nlm.nih.gov/pubmed/20563249
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