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PTEN and Other PtdIns(3,4,5)P(3) Lipid Phosphatases in Breast Cancer
The phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is hyperactivated in ~70% of breast cancers. Class I PI3K generates PtdIns(3,4,5)P(3) at the plasma membrane in response to growth factor stimulation, leading to AKT activation to drive cell proliferation, survival and migration. PTEN negat...
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| Publicado no: | Int J Mol Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7730566/ https://ncbi.nlm.nih.gov/pubmed/33276499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239189 |
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