PtdIns(3,4,5)P(3)-dependent Rac exchanger 1 (P-Rex1) promotes mammary tumor initiation and metastasis

The Rac-GEF, P-Rex1, activates Rac1 signaling downstream of G protein-coupled receptors and PI3K. Increased P-Rex1 expression promotes melanoma progression; however, its role in breast cancer is complex, with differing reports of the effect of its expression on disease outcome. To address this we an...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Srijakotre, Nuthasuda, Liu, Heng-Jia, Nobis, Max, Man, Joey, Yip, Hon Yan Kelvin, Papa, Antonella, Abud, Helen E., Anderson, Kurt I., Welch, Heidi C. E., Tiganis, Tony, Timpson, Paul, McLean, Catriona A., Ooms, Lisa M., Mitchell, Christina A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668035/
https://ncbi.nlm.nih.gov/pubmed/33097662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006445117
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