Foam Cell Induction Activates AMPK But Uncouples Its Regulation of Autophagy and Lysosomal Homeostasis

The dysregulation of macrophage lipid metabolism drives atherosclerosis. AMP-activated protein kinase (AMPK) is a master regulator of cellular energetics and plays essential roles regulating macrophage lipid dynamics. Here, we investigated the consequences of atherogenic lipoprotein-induced foam cel...

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Udgivet i:Int J Mol Sci
Main Authors: LeBlond, Nicholas D., Nunes, Julia R. C., Smith, Tyler K. T., O’Dwyer, Conor, Robichaud, Sabrina, Gadde, Suresh, Côté, Marceline, Kemp, Bruce E., Ouimet, Mireille, Fullerton, Morgan D.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7730064/
https://ncbi.nlm.nih.gov/pubmed/33261140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21239033
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