Unravelling the intricate cooperativity of subunit gating in P2X2 ion channels

Ionotropic purinergic (P2X) receptors are trimeric channels that are activated by the binding of ATP. They are involved in multiple physiological functions, including synaptic transmission, pain and inflammation. The mechanism of activation is still elusive. Here we kinetically unraveled and quantif...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Sattler, Christian, Eick, Thomas, Hummert, Sabine, Schulz, Eckhard, Schmauder, Ralf, Schweinitz, Andrea, Unzeitig, Christopher, Schwede, Frank, Benndorf, Klaus
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7729398/
https://ncbi.nlm.nih.gov/pubmed/33303878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78672-w
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