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CB(1)R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance
The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulates leptin bioavailability and bioactivity. Its reduced levels in diet-induced obesity (DIO) contribute to hyperleptinemia and leptin resistance, effects that are regulated by the endocannabinoid (eCB)/CB(1)R system. Here w...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | eLife |
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| Κύριοι συγγραφείς: | , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
eLife Sciences Publications, Ltd
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7728447/ https://ncbi.nlm.nih.gov/pubmed/33210603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60771 |
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