CB(1)R regulates soluble leptin receptor levels via CHOP, contributing to hepatic leptin resistance

The soluble isoform of leptin receptor (sOb-R), secreted by the liver, regulates leptin bioavailability and bioactivity. Its reduced levels in diet-induced obesity (DIO) contribute to hyperleptinemia and leptin resistance, effects that are regulated by the endocannabinoid (eCB)/CB(1)R system. Here w...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Drori, Adi, Gammal, Asaad, Azar, Shahar, Hinden, Liad, Hadar, Rivka, Wesley, Daniel, Nemirovski, Alina, Szanda, Gergő, Salton, Maayan, Tirosh, Boaz, Tam, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7728447/
https://ncbi.nlm.nih.gov/pubmed/33210603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.60771
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