Peripheral cannabinoid-1 receptor blockade restores hypothalamic leptin signaling

OBJECTIVE: In visceral obesity, an overactive endocannabinoid/CB(1) receptor (CB(1)R) system promotes increased caloric intake and decreases energy expenditure, which are mitigated by global or peripheral CB(1)R blockade. In mice with diet-induced obesity (DIO), inhibition of food intake by the peri...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Tam, Joseph, Szanda, Gergő, Drori, Adi, Liu, Ziyi, Cinar, Resat, Kashiwaya, Yoshihiro, Reitman, Marc L., Kunos, George
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5641628/
https://ncbi.nlm.nih.gov/pubmed/29031713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.06.010
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