Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

Obesity-related leptin resistance manifests in loss of leptin’s ability to reduce appetite and increase energy expenditure. Obesity is also associated with increased activity of the endocannabinoid system, and CB(1) receptor (CB(1)R) inverse agonists reduce body weight and the associated metabolic c...

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Detalhes bibliográficos
Main Authors: Tam, Joseph, Cinar, Resat, Liu, Jie, Godlewski, Grzegorz, Wesley, Daniel, Jourdan, Tony, Szanda, Gergö, Mukhopadhyay, Bani, Chedester, Lee, Liow, Jeih-San, Innis, Robert B., Cheng, Kejun, Rice, Kenner C., Deschamps, Jeffrey R., Chorvat, Robert J., McElroy, John F., Kunos, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832894/
https://ncbi.nlm.nih.gov/pubmed/22841573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.07.002
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