Structural Basis of Species-Dependent Differential Affinity of 6-Alkoxy-5-Aryl-3-Pyridinecarboxamide Cannabinoid-1 Receptor Antagonists

6-Alkoxy-5-aryl-3-pyridincarboxamides, including the brain-penetrant compound 14g [5-(4-chlorophenyl)-6-(cyclopropylmethoxy)-N-[(1R,2R)-2-hydroxy-cyclohexyl]-3-pyridinecarboxamide] and its peripherally restricted analog 14h [5-(4-chlorophenyl)-N-[(1R,2R)-2-hydroxycyclohexyl]-6-(2-methoxyethoxy)-3-py...

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Detalhes bibliográficos
Publicado no:Mol Pharmacol
Main Authors: Iyer, Malliga R., Cinar, Resat, Liu, Jie, Godlewski, Grzegorz, Szanda, Gergö, Puhl, Henry, Ikeda, Stephen R., Deschamps, Jeffrey, Lee, Yong-Sok, Steinbach, Peter J., Kunos, George
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Accelerated Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518088/
https://ncbi.nlm.nih.gov/pubmed/26013543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.115.098541
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