NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease

Granulocytes from patients with chronic granulomatous disease (CGD) have dysfunctional phagocyte reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase that fails to generate sufficient antimicrobial reactive oxidative species. CGD patients with severe persistent fungal or bacterial inf...

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Veröffentlicht in:Blood Adv
Hauptverfasser: De Ravin, Suk See, Brault, Julie, Meis, Ronald J., Li, Linhong, Theobald, Narda, Bonifacino, Aylin C., Lei, Hong, Liu, Taylor Q., Koontz, Sherry, Corsino, Cristina, Zarakas, Marissa A., Desai, Jigar V., Clark, Aaron B., Choi, Uimook, Metzger, Mark E., West, Kamille, Highfill, Steven L., Kang, Elizabeth, Kuhns, Douglas B., Lionakis, Michail S., Stroncek, David F., Dunbar, Cynthia E., Tisdale, John F., Donahue, Robert E., Dahl, Gary A., Malech, Harry L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Phagocytes, Granulocytes, and Myelopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724899/
https://ncbi.nlm.nih.gov/pubmed/33284949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003224
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