NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease

Granulocytes from patients with chronic granulomatous disease (CGD) have dysfunctional phagocyte reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase that fails to generate sufficient antimicrobial reactive oxidative species. CGD patients with severe persistent fungal or bacterial inf...

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Detalles Bibliográficos
Publicado en:Blood Adv
Main Authors: De Ravin, Suk See, Brault, Julie, Meis, Ronald J., Li, Linhong, Theobald, Narda, Bonifacino, Aylin C., Lei, Hong, Liu, Taylor Q., Koontz, Sherry, Corsino, Cristina, Zarakas, Marissa A., Desai, Jigar V., Clark, Aaron B., Choi, Uimook, Metzger, Mark E., West, Kamille, Highfill, Steven L., Kang, Elizabeth, Kuhns, Douglas B., Lionakis, Michail S., Stroncek, David F., Dunbar, Cynthia E., Tisdale, John F., Donahue, Robert E., Dahl, Gary A., Malech, Harry L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2020
Assuntos:
Phagocytes, Granulocytes, and Myelopoiesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7724899/
https://ncbi.nlm.nih.gov/pubmed/33284949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003224
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