Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis

Mutations in more than 15 genes are now known to cause severe congenital neutropenia (SCN); however, the pathologic mechanisms of most genetic defects are not fully defined. Deficiency of G6PC3, a glucose-6-phosphatase, causes a rare multisystem syndrome with SCN first described in 2009. We identifi...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: McDermott, David H., De Ravin, Suk See, Jun, Hyun Sik, Liu, Qian, Priel, Debra A. Long, Noel, Pierre, Takemoto, Clifford M., Ojode, Teresa, Paul, Scott M., Dunsmore, Kimberly P., Hilligoss, Dianne, Marquesen, Martha, Ulrick, Jean, Kuhns, Douglas B., Chou, Janice Y., Malech, Harry L., Murphy, Philip M.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society of Hematology 2010
الموضوعات:
Phagocytes, Granulocytes, and Myelopoiesis
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974587/
https://ncbi.nlm.nih.gov/pubmed/20616219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-265942
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