The Structures of Gd(III) Chelates Conjugated at the Periphery of 3-(1’-Hexyloxy)ethyl-3-devinylpyropheophorbide-a (HPPH) Have a Significant Impact on the Imaging and Therapy of Cancer

3-(1’-Hexyloxyethyl)-3-devinyl-pyropheophorbide-a (HPPH or Photochlor), a tumor-avid chlorophyll-a derivative currently undergoing human clinical trials, was conjugated at various peripheral positions (position-17 or 20) of HPPH with either Gd(III)-aminobenzyl-DTPA (Gd(III) DTPA) or Gd(III)-aminoeth...

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Publicado en:ChemMedChem
Autores principales: Zhang, Shunqing, Cheruku, Ravindra R., Dukh, Mykhaylo, Tabaczynski, Walter, Patel, Nayan J., White, William H., Missert, Joseph R., Spernyak, Joseph A., Pandey, Ravindra K.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7722155/
https://ncbi.nlm.nih.gov/pubmed/32916033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000449
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