Synthesis of Tumor-Avid Photosensitizer-Gd(III)DTPA Conjugates: Impact of the Number of Gadolinium Units in T(1)/T(2) Relaxivity, Intracellular localization and Photosensitizing Efficacy

To develop novel bifunctional agents for tumor imaging (MR) and photodynamic therapy (PDT) certain tumor-avid photosensitizers derived from chlorophyll-a were conjugated with variable number of Gd(III)aminobenzyl DTPA moieties. All the conjugates containing three or six gadolinium units showed signi...

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Main Authors: Goswami, Lalit N., White, William H., Spernyak, Joseph A., Ethirajan, Manivannan, Chen, Yihui, Missert, Joseph R., Morgan, Janet, Mazurchuk, Richard, Pandey, Ravindra K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2889622/
https://ncbi.nlm.nih.gov/pubmed/20387863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc9005305
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