Conjugation of cRGD Peptide to Chlorophyll-a Based Photosensitizer (HPPH) Alters its Pharmacokinetics with Enhanced Tumor-Imaging and Photosensitizing (PDT) Efficacy

The α(v)β(3) integrin receptor plays an important role in human metastasis and tumor-induced angiogenesis. Cyclic Arg-Gly-Asp (cRGD) peptide represents a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis. For developing photosen...

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Main Authors: Srivatsan, Avinash, Ethirajan, Manivannan, Pandey, Suresh K., Dubey, Shipra, Zheng, Xiang, Liu, Ting-Hsiu, Shibata, Masayuki, Missert, Joseph, Morgan, Janet, Pandey, Ravindra K.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148296/
https://ncbi.nlm.nih.gov/pubmed/21702452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp200018y
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