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Synthesis of Tumor-Avid Photosensitizer-Gd(III)DTPA Conjugates: Impact of the Number of Gadolinium Units in T(1)/T(2) Relaxivity, Intracellular localization and Photosensitizing Efficacy
To develop novel bifunctional agents for tumor imaging (MR) and photodynamic therapy (PDT) certain tumor-avid photosensitizers derived from chlorophyll-a were conjugated with variable number of Gd(III)aminobenzyl DTPA moieties. All the conjugates containing three or six gadolinium units showed signi...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2889622/ https://ncbi.nlm.nih.gov/pubmed/20387863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc9005305 |
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