Hexylether Derivative of Pyropheophorbide-a (HPPH) on Conjugating with 3Gadolinium(III) Aminobenzyldiethylenetriaminepentaacetic Acid Shows Potential for In vivo Tumor-Imaging (MR, Fluorescence) and Photodynamic Therapy

Conjugates of 3-(1′-hexyloxyethyl)-3-devinyl pyropheophorbide-a (HPPH) with multiple Gd(III)aminobenzyl diethylenetriamine pentacetic acid (ADTPA) moieties were evaluated for tumor imaging and photodynamic therapy (PDT). In vivo studies performed in both mice and rat tumor models resulted in a signi...

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Main Authors: Spernyak, Joseph A., White, William H., Ethirajan, Manivannan, Patel, Nayan J., Goswami, Lalit, Chen, Yihui, Turowski, Steven, Missert, Joseph. R., Batt, Carrie, Mazurchuk, Richard, Pandey, Ravindra K.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874103/
https://ncbi.nlm.nih.gov/pubmed/20387862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bc9005317
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