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Stability and cell permeability of sulfonyl fluorides in the design of Lys-covalent antagonists of protein-protein interactions
Recently we reported on aryl-fluorosulfates as possible stable and effective electrophiles for the design of lysine covalent, cell permeable antagonists of protein-protein interactions (PPIs). Here we revisit the use of aryl-sulfonyl fluorides as Lys-targeting moieties, incorporating these electroph...
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| Опубликовано в: : | ChemMedChem |
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| Главные авторы: | , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7722097/ https://ncbi.nlm.nih.gov/pubmed/32790900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000355 |
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