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N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists
Recently, it was reported that tetra-peptides cyclized via lactam bond between the amino terminus and a glutamic residue in position 4 (termed here N-lock) can nucleate helix formation in longer peptides. We applied such strategy to derive N-locked covalent BH3 peptides that were designed to selecti...
Gorde:
| Argitaratua izan da: | Chem Biol Drug Des |
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| Egile Nagusiak: | , , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2020
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7568863/ https://ncbi.nlm.nih.gov/pubmed/31898401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13661 |
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