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N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists

Recently, it was reported that tetra-peptides cyclized via lactam bond between the amino terminus and a glutamic residue in position 4 (termed here N-lock) can nucleate helix formation in longer peptides. We applied such strategy to derive N-locked covalent BH3 peptides that were designed to selecti...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chem Biol Drug Des
Egile Nagusiak: Baggio, Carlo, Udompholkul, Parima, Gambini, Luca, Jossart, Jennifer, Salem, Ahmed F., Håkansson, Maria, Perry, J. Jefferson P., Pellecchia, Maurizio
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568863/
https://ncbi.nlm.nih.gov/pubmed/31898401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13661
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