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N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists
Recently, it was reported that tetra-peptides cyclized via lactam bond between the amino terminus and a glutamic residue in position 4 (termed here N-lock) can nucleate helix formation in longer peptides. We applied such strategy to derive N-locked covalent BH3 peptides that were designed to selecti...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Chem Biol Drug Des |
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| Κύριοι συγγραφείς: | , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7568863/ https://ncbi.nlm.nih.gov/pubmed/31898401 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.13661 |
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