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Structural basis for polarized elongation of actin filaments

Actin filaments elongate and shorten much faster at their barbed end than their pointed end, but the molecular basis of this difference has not been understood. We use all-atom molecular dynamics simulations to investigate the properties of subunits at both ends of the filament. The terminal subunit...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Zsolnay, Vilmos, Katkar, Harshwardhan H., Chou, Steven Z., Pollard, Thomas D., Voth, Gregory A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720195/
https://ncbi.nlm.nih.gov/pubmed/33199648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011128117
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