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Structural basis for polarized elongation of actin filaments

Actin filaments elongate and shorten much faster at their barbed end than their pointed end, but the molecular basis of this difference has not been understood. We use all-atom molecular dynamics simulations to investigate the properties of subunits at both ends of the filament. The terminal subunit...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Zsolnay, Vilmos, Katkar, Harshwardhan H., Chou, Steven Z., Pollard, Thomas D., Voth, Gregory A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720195/
https://ncbi.nlm.nih.gov/pubmed/33199648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2011128117
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