Markov state modeling reveals alternative unbinding pathways for peptide–MHC complexes

Peptide binding to major histocompatibility complexes (MHCs) is a central component of the immune system, and understanding the mechanism behind stable peptide–MHC binding will aid the development of immunotherapies. While MHC binding is mostly influenced by the identity of the so-called anchor posi...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Abella, Jayvee R., Antunes, Dinler, Jackson, Kyle, Lizée, Gregory, Clementi, Cecilia, Kavraki, Lydia E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7720115/
https://ncbi.nlm.nih.gov/pubmed/33184174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007246117
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