Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver

Ascorbic acid (AA, vitamin C) serves as a cofactor for ten-eleven translocation (TET) enzymes and induces DNA demethylation in vitro. However, its role in DNA demethylation in vivo remains unclear. We previously reported that DNA demethylation in the mouse liver was enhanced during the suckling peri...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kawahori, Kenichi, Kondo, Yoshitaka, Yuan, Xunmei, Kawasaki, Yuki, Hanzawa, Nozomi, Tsujimoto, Kazutaka, Wada, Fumiko, Kohda, Takashi, Ishigami, Akihito, Yamada, Tetsuya, Ogawa, Yoshihiro, Hashimoto, Koshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718234/
https://ncbi.nlm.nih.gov/pubmed/33277554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77962-7
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