Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver

Ascorbic acid (AA, vitamin C) serves as a cofactor for ten-eleven translocation (TET) enzymes and induces DNA demethylation in vitro. However, its role in DNA demethylation in vivo remains unclear. We previously reported that DNA demethylation in the mouse liver was enhanced during the suckling peri...

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Udgivet i:Sci Rep
Main Authors: Kawahori, Kenichi, Kondo, Yoshitaka, Yuan, Xunmei, Kawasaki, Yuki, Hanzawa, Nozomi, Tsujimoto, Kazutaka, Wada, Fumiko, Kohda, Takashi, Ishigami, Akihito, Yamada, Tetsuya, Ogawa, Yoshihiro, Hashimoto, Koshi
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718234/
https://ncbi.nlm.nih.gov/pubmed/33277554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77962-7
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