Ascorbic acid during the suckling period is required for proper DNA demethylation in the liver

Ascorbic acid (AA, vitamin C) serves as a cofactor for ten-eleven translocation (TET) enzymes and induces DNA demethylation in vitro. However, its role in DNA demethylation in vivo remains unclear. We previously reported that DNA demethylation in the mouse liver was enhanced during the suckling peri...

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Publicat a:Sci Rep
Autors principals: Kawahori, Kenichi, Kondo, Yoshitaka, Yuan, Xunmei, Kawasaki, Yuki, Hanzawa, Nozomi, Tsujimoto, Kazutaka, Wada, Fumiko, Kohda, Takashi, Ishigami, Akihito, Yamada, Tetsuya, Ogawa, Yoshihiro, Hashimoto, Koshi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718234/
https://ncbi.nlm.nih.gov/pubmed/33277554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77962-7
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