Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing

Recently, we reported PPARα-dependent DNA demethylation of the Fgf21 promoter in the postnatal mouse liver, where reduced DNA methylation is associated with enhanced gene expression after PPARα activation. However, there is no direct evidence for the effect of site-specific DNA methylation on gene e...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Hanzawa, Nozomi, Hashimoto, Koshi, Yuan, Xunmei, Kawahori, Kenichi, Tsujimoto, Kazutaka, Hamaguchi, Miho, Tanaka, Toshiya, Nagaoka, Yuya, Nishina, Hiroshi, Morita, Sumiyo, Hatada, Izuho, Yamada, Tetsuya, Ogawa, Yoshihiro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083849/
https://ncbi.nlm.nih.gov/pubmed/32198422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62035-6
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