Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing

Recently, we reported PPARα-dependent DNA demethylation of the Fgf21 promoter in the postnatal mouse liver, where reduced DNA methylation is associated with enhanced gene expression after PPARα activation. However, there is no direct evidence for the effect of site-specific DNA methylation on gene e...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Hanzawa, Nozomi, Hashimoto, Koshi, Yuan, Xunmei, Kawahori, Kenichi, Tsujimoto, Kazutaka, Hamaguchi, Miho, Tanaka, Toshiya, Nagaoka, Yuya, Nishina, Hiroshi, Morita, Sumiyo, Hatada, Izuho, Yamada, Tetsuya, Ogawa, Yoshihiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083849/
https://ncbi.nlm.nih.gov/pubmed/32198422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62035-6
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