Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing

Recently, we reported PPARα-dependent DNA demethylation of the Fgf21 promoter in the postnatal mouse liver, where reduced DNA methylation is associated with enhanced gene expression after PPARα activation. However, there is no direct evidence for the effect of site-specific DNA methylation on gene e...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Hanzawa, Nozomi, Hashimoto, Koshi, Yuan, Xunmei, Kawahori, Kenichi, Tsujimoto, Kazutaka, Hamaguchi, Miho, Tanaka, Toshiya, Nagaoka, Yuya, Nishina, Hiroshi, Morita, Sumiyo, Hatada, Izuho, Yamada, Tetsuya, Ogawa, Yoshihiro
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7083849/
https://ncbi.nlm.nih.gov/pubmed/32198422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-62035-6
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky