Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

BACKGROUND: Epigenetic modifications, including DNA methylation, play an important role in gene silencing and genome stability. Consequently, epigenetic dysregulation can cause several diseases, such as cancer, obesity, diabetes, autism, and imprinting disorders. RESULTS: We validate three methods f...

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Vydáno v:Genome Biol
Hlavní autoři: Horii, Takuro, Morita, Sumiyo, Hino, Shinjiro, Kimura, Mika, Hino, Yuko, Kogo, Hiroshi, Nakao, Mitsuyoshi, Hatada, Izuho
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110793/
https://ncbi.nlm.nih.gov/pubmed/32234052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01991-8
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