Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome

BACKGROUND: Epigenetic modifications, including DNA methylation, play an important role in gene silencing and genome stability. Consequently, epigenetic dysregulation can cause several diseases, such as cancer, obesity, diabetes, autism, and imprinting disorders. RESULTS: We validate three methods f...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Horii, Takuro, Morita, Sumiyo, Hino, Shinjiro, Kimura, Mika, Hino, Yuko, Kogo, Hiroshi, Nakao, Mitsuyoshi, Hatada, Izuho
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7110793/
https://ncbi.nlm.nih.gov/pubmed/32234052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01991-8
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados