The ubiquitin ligase WWP1 contributes to shifts in matrix proteolytic profiles and a myocardial aging phenotype with diastolic heart

Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular hypertrophy (LVH) commonly occurs as a function of age and can cause heart failure (HF) with a preserved ejection fraction (EF; HFpEF). We hypot...

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Bibliografiska uppgifter
I publikationen:Am J Physiol Heart Circ Physiol
Huvudupphovsmän: Matesic, Lydia E., Freeburg, Lisa A., Snyder, Laura B., Duncan, Lauren-Ashley, Moore, Amber, Perreault, Paige E., Zellars, Kia N., Goldsmith, Edie C., Spinale, Francis G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2020
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7717125/
https://ncbi.nlm.nih.gov/pubmed/32822210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00620.2019
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