The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

In general, epidermal growth factor receptor family members stimulate cell proliferation. In contrast, at least one HER4 isoform, JM-a/Cyt1, inhibits cell growth after undergoing a two-step proteolytic cleavage that first produces a membrane-anchored 80-kDa fragment (m80(HER4)) and subsequently libe...

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Detalhes bibliográficos
Main Authors: Feng, Shu-Mang, Muraoka-Cook, Rebecca S., Hunter, Debra, Sandahl, Melissa A., Caskey, Laura S., Miyazawa, Keiji, Atfi, Azeddine, Earp, H. Shelton
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630679/
https://ncbi.nlm.nih.gov/pubmed/19047365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00595-08
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