The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

In general, epidermal growth factor receptor family members stimulate cell proliferation. In contrast, at least one HER4 isoform, JM-a/Cyt1, inhibits cell growth after undergoing a two-step proteolytic cleavage that first produces a membrane-anchored 80-kDa fragment (m80(HER4)) and subsequently libe...

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Bibliografiske detaljer
Main Authors: Feng, Shu-Mang, Muraoka-Cook, Rebecca S., Hunter, Debra, Sandahl, Melissa A., Caskey, Laura S., Miyazawa, Keiji, Atfi, Azeddine, Earp, H. Shelton
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2630679/
https://ncbi.nlm.nih.gov/pubmed/19047365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00595-08
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