THE HER4 CYTOPLASMIC DOMAIN, BUT NOT ITS C-TERMINUS, INHIBITS MAMMARY CELL PROLIFERATION

Unlike the proliferative action of other EGF receptor family members, HER4/ErbB4 is often associated with growth inhibitory and differentiation signaling. These actions may involve HER4 two-step proteolytic processing by intra-membraneous γ-secretase, releasing the soluble, intracellular 80kDa HER4...

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Autores principales: Feng, Shu-Mang, Sartor, Carolyn I., Hunter, Debra, Zhou, Hong, Yang, Xihui, Caskey, Laura S., Dy, Ruth, Muraoka-Cook, Rebecca S., Earp, H. Shelton
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917064/
https://ncbi.nlm.nih.gov/pubmed/17505063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2006-0101
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