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HER4 D-box sequences regulate mitotic progression and degradation of the nuclear HER4 cleavage product, s80(HER4)

Heregulin-mediated activation of HER4 initiates receptor cleavage (releasing an 80-kDa HER4 intracellular domain, s80(HER4), containing nuclear localization sequences) and results in G2/M delay by unknown signaling mechanisms. We report herein that s80(HER4) contains a functional cyclin B-like seque...

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Detalhes bibliográficos
Main Authors: Strunk, Karen E., Husted, Carty, Miraglia, Leah C., Sandahl, Melissa, Rearick, William A., Hunter, Debra M., Earp, H. Shelton, Muraoka-Cook, Rebecca S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2917069/
https://ncbi.nlm.nih.gov/pubmed/17638867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-4145
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