Study of the effect of the introduction of mitochondrial import determinants into the gRNA structure on the activity of the gRNA/SpCas9 complex in vitro

It has long been known that defects in the structure of the mitochondrial genome can cause various neuromuscular and neurodegenerative diseases. Nevertheless, at present there is no effective method for treating mitochondrial diseases. The major problem with the treatment of such diseases is associa...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Vavilovskii Zhurnal Genet Selektsii
Prif Awduron: Zakirova, E.G., Vyatkin, Y.V., Verechshagina, N.A., Muzyka, V.V., Mazunin, I.O., Orishchenko, K.E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Federal Research Center Institute of Cytology and Genetics of Siberian Branch of the Russian Academy of Sciences 2020
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7716540/
https://ncbi.nlm.nih.gov/pubmed/33659835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18699/VJ20.643
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