MODL-27. MEK INHIBITION WITH TRAMETINIB SLOWS PROGRESSION OF MEDULLOBLASTOMA AND ATYPICAL TERATOID RHABDOID TUMOR IN ORTHOTOPIC XENOGRAFT MURINE MODEL

BACKGROUND: Combination of surgery, chemotherapy, autologous transplantation, irradiation constitutes treatment of CNS embryonal-cell tumors (Medulloblastoma-MBL, atypical teratoid rhabdoid tumor-AT/RT). Targeted agents to improve survival and decrease side effects are necessary. We hypothesize that...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neuro Oncol
Prif Awduron: Mushrif, Sujata, Hung, Long, Muthugounder, Sakunthala, Asgharzadeh, Shahab
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2020
Pynciau:
Preclinical Models/Experimental Therapy/Drug Discovery
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715828/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.600
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