MODL-27. MEK INHIBITION WITH TRAMETINIB SLOWS PROGRESSION OF MEDULLOBLASTOMA AND ATYPICAL TERATOID RHABDOID TUMOR IN ORTHOTOPIC XENOGRAFT MURINE MODEL

BACKGROUND: Combination of surgery, chemotherapy, autologous transplantation, irradiation constitutes treatment of CNS embryonal-cell tumors (Medulloblastoma-MBL, atypical teratoid rhabdoid tumor-AT/RT). Targeted agents to improve survival and decrease side effects are necessary. We hypothesize that...

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Publicado en:Neuro Oncol
Autores principales: Mushrif, Sujata, Hung, Long, Muthugounder, Sakunthala, Asgharzadeh, Shahab
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Preclinical Models/Experimental Therapy/Drug Discovery
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715828/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.600
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