MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX)

A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model. Seven weeks after implantation, PDOX nude mice were divided into the following groups: untreated control (n = 7); g...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Kawaguchi, Kei, Igarashi, Kentaro, Murakami, Takashi, Kiyuna, Tasuku, Lwin, Thinzar M., Hwang, Ho Kyoung, Delong, Jonathan C., Clary, Bryan M., Bouvet, Michael, Unno, Michiaki, Hoffman, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564580/
https://ncbi.nlm.nih.gov/pubmed/28537897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17667
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