DIPG-32. AKT SIGNALING DRIVES RESISTANCE TO ONC201 IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive, childhood brainstem cancer with a median overall survival of 10 months post diagnosis. Remarkably, 80–90% of patients harbor recurring point mutation in histone H3, which induces a lysine for methionine substitution at amino acid 27 (H3...

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Publicat a:Neuro Oncol
Autors principals: Jackson, Evangeline R, Duchatel, Ryan J, Mannan, Abdul, Hulleman, Esther, Carcaboso, Angel M, Monje, Michelle, McCowage, Geoff B, Alvaro, Frank, Dun, Matthew D
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Diffuse Midline Glioma/DIPG
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715600/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.080
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