DIPG-29. PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE (PI3K) INHIBITION DRIVES PROTEIN KINASE C ACTIVATION (PKC) IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

Recurring somatic mutations and gene amplifications to members of the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) signaling axis are overarching contributors to the aggressive growth and survival of diffuse intrinsic pontine gliomas (DIPG). However, targeting PI3K has thus far failed to im...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Neuro Oncol
Päätekijät: Duchatel, Ryan J, Mannan, Abdul, Jackson, Evangeline R, Staudt, Dilana, Skerrett-Byrne, David A, Jamaluddin, M Fairuz B, Woldu, Ameha S, Douglas, Alicia, Hulleman, Esther, Carcaboso, Angel M, Monje, Michelle, Alvaro, Frank, Tsoli, Maria, Ziegler, David S, Dun, Matthew D
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2020
Aiheet:
Diffuse Midline Glioma/DIPG
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715471/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.078
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