DIPG-03. TARGETING PI3K USING THE BLOOD BRAIN BARRIER PENETRABLE INHIBITOR, GDC-0084, FOR THE TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)

BACKGROUND: Diffuse Intrinsic Pontine Glioma (DIPG) is a devastating, incurable childhood brain cancer. 80% of patients harbour a genetic lesion to Histone-H3 with a substitution of lysine 27 for a methionine (K27M) (H3F3A/H3.3 and HIST1H3B/H3.1) which results in the loss of methylation, interfering...

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Vydáno v:Neuro Oncol
Hlavní autoři: Duchatel, Ryan, Jackson, Evangeline, Patabendige, Adjanie, Cain, Jason, Tsoli, Maria, Monje, Michelle, Alvaro, Frank, Ziegler, David, Dun, Matthew
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Diffuse Intrinsic Pontine Glioma (DIPG)
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6477226/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz036.024
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