DIPG-15. POLYAMINE PATHWAY INHIBITION IS A POTENT NOVEL THERAPEUTIC STRATEGY AGAINST DIFFUSE INTRINSIC PONTINE GLIOMA

DIPG is an aggressive paediatric brainstem tumour, with a median survival of less than 1 year. Polyamines are intracellular polycations that control important aspects of cell growth and are often upregulated in cancer. Difluoromethylornithine (DFMO) is an FDA-approved inhibitor of the enzyme ornithi...

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Vydáno v:Neuro Oncol
Hlavní autoři: Khan, Aaminah, Gamble, Laura, Upton, Dannielle, Yu, Denise, Ehteda, Anahid, Pandher, Ruby, Mayoh, Chelsea, Burns, Mark, Norris, Murray, Haber, Michelle, Tsoli, Maria, Ziegler, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Diffuse Midline Glioma/DIPG
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715550/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.065
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