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Evaluation of [(13)N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain
PURPOSE: The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalysed conversion of glutamate to glutamine requires ammonia, we evaluated whether [(1...
Zapisane w:
| Wydane w: | EJNMMI Res |
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| Główni autorzy: | , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
Springer Berlin Heidelberg
2020
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7714883/ https://ncbi.nlm.nih.gov/pubmed/33270177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-020-00731-0 |
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