Evaluation of [(13)N]ammonia positron emission tomography as a potential method for quantifying glutamine synthetase activity in the human brain

PURPOSE: The conversion of synaptic glutamate to glutamine in astrocytes by glutamine synthetase (GS) is critical to maintaining healthy brain activity and may be disrupted in several brain disorders. As the GS catalysed conversion of glutamate to glutamine requires ammonia, we evaluated whether [(1...

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Detalhes bibliográficos
Publicado no:EJNMMI Res
Main Authors: Egerton, Alice, Dunn, Joel T., Singh, Nisha, Yu, Zilin, O’Doherty, Jim, Koychev, Ivan, Webb, Jessica, Claridge, Simon, Turkheimer, Federico E., Marsden, Paul K., Hammers, Alexander, Gee, Antony
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2020
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714883/
https://ncbi.nlm.nih.gov/pubmed/33270177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-020-00731-0
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