Electronic DNA analysis of CSF cell-free tumor DNA to quantify multi-gene molecular response in pediatric high-grade glioma

PURPOSE: Pediatric high-grade glioma (pHGG) diagnosis portends poor prognosis and therapeutic monitoring remains difficult. Tumors release cell-free tumor DNA (cf-tDNA) into cerebrospinal fluid (CSF), allowing for potential detection of tumor-associated mutations by CSF sampling. We hypothesized tha...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Bruzek, Amy K., Ravi, Karthik, Muruganand, Ashwath, Wadden, Jack, Babila, Clarissa May, Cantor, Evan, Tunkle, Leo, Wierzbicki, Kyle, Stallard, Stefanie, Dickson, Robert P., Wolfe, Ian, Mody, Rajen, Schwartz, Jonathan, Franson, Andrea, Robertson, Patricia L., Muraszko, Karin M., Maher, Cormac O., Garton, Hugh J.L., Qin, Tingtin, Koschmann, Carl
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710567/
https://ncbi.nlm.nih.gov/pubmed/33087334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2066
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