Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation

Specific E3 ligases target tumor suppressors for degradation. Inhibition of such E3 ligases may be an important approach to cancer treatment. RNF146 is a RING domain and PARylation-dependent E3 ligase that functions as an activator of the β-catenin/Wnt and YAP/Hippo pathways by targeting the degrada...

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Bibliographic Details
Published in:Mol Cell Proteomics
Main Authors: Nie, Litong, Wang, Chao, Li, Nan, Feng, Xu, Lee, Namsoo, Su, Dan, Tang, Mengfan, Yao, Fan, Chen, Junjie
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710139/
https://ncbi.nlm.nih.gov/pubmed/32958691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002290
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