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Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation
Specific E3 ligases target tumor suppressors for degradation. Inhibition of such E3 ligases may be an important approach to cancer treatment. RNF146 is a RING domain and PARylation-dependent E3 ligase that functions as an activator of the β-catenin/Wnt and YAP/Hippo pathways by targeting the degrada...
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| Publicado no: | Mol Cell Proteomics |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7710139/ https://ncbi.nlm.nih.gov/pubmed/32958691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.RA120.002290 |
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