Teleological role of L-2-hydroxyglutarate dehydrogenase in the kidney

L-2-hydroxyglutarate (L-2HG) is an oncometabolite found elevated in renal tumors. However, this molecule might have physiological roles that extend beyond its association with cancer, as L-2HG levels are elevated in response to hypoxia and during Drosophila larval development. L-2HG is known to be m...

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Udgivet i:Dis Model Mech
Main Authors: Brinkley, Garrett, Nam, Hyeyoung, Shim, Eunhee, Kirkman, Richard, Kundu, Anirban, Karki, Suman, Heidarian, Yasaman, Tennessen, Jason M., Liu, Juan, Locasale, Jason W., Guo, Tao, Wei, Shi, Gordetsky, Jennifer, Johnson-Pais, Teresa L., Absher, Devin, Rakheja, Dinesh, Challa, Anil K., Sudarshan, Sunil
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710027/
https://ncbi.nlm.nih.gov/pubmed/32928875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.045898
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