PRDM16 suppresses HIF-targeted gene expression in kidney cancer

Analysis of transcriptomic data demonstrates extensive epigenetic gene silencing of the transcription factor PRDM16 in renal cancer. We show that restoration of PRDM16 in RCC cells suppresses in vivo tumor growth. RNaseq analysis reveals that PRDM16 imparts a predominantly repressive effect on the R...

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Detaylı Bibliyografya
Yayımlandı:J Exp Med
Asıl Yazarlar: Kundu, Anirban, Nam, Hyeyoung, Shelar, Sandeep, Chandrashekar, Darshan S., Brinkley, Garrett, Karki, Suman, Mitchell, Tanecia, Livi, Carolina B., Buckhaults, Phillip, Kirkman, Richard, Tang, Yawen, Rowe, Glenn C., Wei, Shi, Varambally, Sooryanarayana, Sudarshan, Sunil
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Rockefeller University Press 2020
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7971134/
https://ncbi.nlm.nih.gov/pubmed/32251515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20191005
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