Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

PURPOSE: Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the contribution of L-2-HG to renal carcinogenesis and insight into the biochemistry and targets of this small molecule remains to be eluc...

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書誌詳細
出版年:Clin Cancer Res
主要な著者: Shelar, Sandeep Balu, Shim, Eun-Hee, Brinkley, Garrett J., Kundu, Anirban, Carobbio, Francesca, Poston, Tyler, Tan, Jubilee, Parekh, Vishwas, Benson, Daniel, Crossman, David K., Buckhaults, Phillip J., Rakheja, Dinesh, Kirkman, Richard, Sato, Yusuke, Ogawa, Seishi, Dutta, Shilpa, Velu, Sadanandan E., Emberley, Ethan, Pan, Alison, Chen, Jason, Huang, Tony, Absher, Devin, Becker, Anja, Kunick, Conrad, Sudarshan, Sunil
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295227/
https://ncbi.nlm.nih.gov/pubmed/30108105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1727
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