Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

PURPOSE: Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the contribution of L-2-HG to renal carcinogenesis and insight into the biochemistry and targets of this small molecule remains to be eluc...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Shelar, Sandeep Balu, Shim, Eun-Hee, Brinkley, Garrett J., Kundu, Anirban, Carobbio, Francesca, Poston, Tyler, Tan, Jubilee, Parekh, Vishwas, Benson, Daniel, Crossman, David K., Buckhaults, Phillip J., Rakheja, Dinesh, Kirkman, Richard, Sato, Yusuke, Ogawa, Seishi, Dutta, Shilpa, Velu, Sadanandan E., Emberley, Ethan, Pan, Alison, Chen, Jason, Huang, Tony, Absher, Devin, Becker, Anja, Kunick, Conrad, Sudarshan, Sunil
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295227/
https://ncbi.nlm.nih.gov/pubmed/30108105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1727
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia