Biochemical and Epigenetic Insights into L-2-Hydroxyglutarate, a Potential Therapeutic Target in Renal Cancer

PURPOSE: Elevation of L-2-hydroxylgutarate (L-2-HG) in renal cell carcinoma (RCC) is due in part to reduced expression of L-2-HG dehydrogenase (L2HGDH). However, the contribution of L-2-HG to renal carcinogenesis and insight into the biochemistry and targets of this small molecule remains to be eluc...

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Foilsithe in:Clin Cancer Res
Main Authors: Shelar, Sandeep Balu, Shim, Eun-Hee, Brinkley, Garrett J., Kundu, Anirban, Carobbio, Francesca, Poston, Tyler, Tan, Jubilee, Parekh, Vishwas, Benson, Daniel, Crossman, David K., Buckhaults, Phillip J., Rakheja, Dinesh, Kirkman, Richard, Sato, Yusuke, Ogawa, Seishi, Dutta, Shilpa, Velu, Sadanandan E., Emberley, Ethan, Pan, Alison, Chen, Jason, Huang, Tony, Absher, Devin, Becker, Anja, Kunick, Conrad, Sudarshan, Sunil
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6295227/
https://ncbi.nlm.nih.gov/pubmed/30108105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1727
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